Imaging butyrylcholinesterase activity in Alzheimer's disease.
نویسندگان
چکیده
Brain-Mind Project and University of Miami School of Medicine, Miami, FL, Departments of Medicine, Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada, Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD, and Laboratory for Neurodegenerative and Aging Research, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA
منابع مشابه
Targeting butyrylcholinesterase for preclinical single photon emission computed tomography (SPECT) imaging of Alzheimer's disease
INTRODUCTION Diagnosis of Alzheimer's disease (AD) in vivo, by molecular imaging of amyloid or tau, is constrained because similar changes can be found in brains of cognitively normal individuals. Butyrylcholinesterase (BChE), which becomes associated with these structures in AD, could elevate the accuracy of AD diagnosis by focusing on BChE pathology in the cerebral cortex, a region of scant B...
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ورودعنوان ژورنال:
- Annals of neurology
دوره 60 6 شماره
صفحات -
تاریخ انتشار 2006